Chimeric nucleolin aptamer with survivin DNAzyme for cancer cell targeted delivery.
نویسندگان
چکیده
A chimeric aptamer-DNAzyme conjugate was generated for the first time using a nucleolin aptamer (NCL-APT) and survivin Dz (Sur_Dz) and exhibited the targeted killing of cancer cells. This proof of concept of using an aptamer for the delivery of DNAzyme can be applied to other cancer types to target survivin in cancer cells in a specific manner.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 32 شماره
صفحات -
تاریخ انتشار 2015